Momentum Animal Cure (MAC) Parasite (P)

MAC-P was established by two Dutch breeders of Spanish purebred horses,

Yeguada Vaessen-Meijs

breeding and riding Pura Raza Española horses since 1992.

We are living in Belgium since 1997.

The picture on the right shows one of our clients:

the famous Dutch singer - songwriter Boudewijn de Groot with the PRE horse Barquero XXI.

The establisment of MAC-P went through years of  research.

We started in 2008 when we tried MAC-P on our twelve  horses. The results were good.

(Please see figure 2a and 2b of one of our horses with endoparasites, resistant to the deworming products that are on the market now).

• Afterwards we started the procedure for the patent in Belgium.

MAC-P was tested twice with the AMES II protocol at the government Flemish Institute for Technological Research.

These tests show that MAC-P can be safely used.

• At the Veterinarian Faculty - Parasitology -  MAC-P was tested on its efficacy by means of  in vitro tests on ascaris suum and on ostertagia o. The test results are good.                                            Please see below: Table 1 and Table 2
• In vivo tests were executed by veterinarians on horses, pigs, cattle, dogs and one cat for endoparasites. The efficacy on ectoparasites was tested on pigeons. The test results are good (please see below).

In November 2010 we filed for the PCT-patent. The US-patent was issued on April 29th 2014. The EU-patent was approved on March 9th 2016.

The invention is demonstrated on the basis of the examples below. These examples do not of course in any way form a limitation of the invention as described above.

RESEARCHES

In vitro test

         Ascaris suum and Ostertagia ostertagi  L3 larvae where cultured on a medium including a concentration range of MAC-Presin. The efficacy of MAC-P on the viability of the larvae was evaluated, by controlling the motility of the larvae under the microscope, after 24 h and 48 h.

         The measured efficacy is the % mortality with regard to the negative controls. The tests were exhibited two times for each species.

         The table below shows the results of the tests. The X-axis shows the concentration of MAC-P resin that is used. The Y –axis shows the amount of larvae that died. The first chart shows the amount of larvae that died after 24 hours, the second after 48 hours.

Results

         Ascaris suum: the results of both experiments reveal a dose dependent effect on the helminths.

O. ostertagi: Both experiments show a doses-dependent effect on the helminths. The highest mortality is found after 48 hours at the highest concentration.

         MAC-P resin has thus an anthelminthic effect for both Ascaris suum and O. ostertagi. The effect is better for Ascaris suum than for O. ostertagi. This can be due to the fact that ostertagia ostertagi larvae don’t feed themselves with the medium, while Ascaris suum larvae do feed themselves with the medium.

The resin probably enters the ostertagia o. larvae through diffusion. This is a novel invention as the ostergia o. causes a lot of damage and economic loss in cattle farming. In US cattle farming there is a yearly loss of 2.000.000.000 dollar (!) because of the resistance of ostertagia o. against the current anthelmintics.

A remedy against ostertagia o. is therefore a much sought after cure. 

Table 1: 1^st and 2^nd Ascaris test

Table 2: 1^st and 2^nd Ostertagia test

In vivo tests:

Material

         The materials used for the experiments below is MAC-P.

The mixture was added to a syringe and orally administered to the animals.

Treatment of pigs

                        Coproscopic flotation test of the faeces of two young pigs (average weight in between 135 and 150 kg) revealed an infection with parasites. The pigs were treated once with 10 g of MAC-P resin mixed with a cereal mixture  and after 13 days the faeces where tested again. The table below shows

Table 3 Pigs

Treatment of horses with MAC-P

         Ten horses seriously infected with parasites were treated once with 30g MAC-P to which a mixture of cereals was optionally added. After ten days a sample of the faeces was taken and sent for coprological examination. Different methods of analysis are known to the skilled person, including the McMaster method. The presence of different parasites was tested via the McMaster method and the macroscopic examination was negative for all the horses.

         One horse was reinfected with trichostrongylus spp. after it was moved to another stable. It was then treated once only with 30g MAC-P, mixed with a cereal mixture. After ten days a faeces sample was taken for a coprological examination. The results of the McMaster method were once again negative.

         One horse (Horse 1) was stabled in a horse-riding centre and had no parasites. The other 70 horses in the horse-riding centre were seriously infected with parasites and were always very hungry.

It was surprisingly found that horse 1 was the only horse with less appetite compared with the others and required less feed. There is a relationship between appetite and infection with endoparasites in horses. Especially, endoparasites that reside in and infect the small and large intestine of a horse cause a deficient nutrient intake through the intestine. The horse needs more food and has an increasing appetite.

         After certain time, the horse got infected by the other horses, and the faeces were tested. The horse was infected with Strongylidae spp. and had an EPG of 1450 (i.e. 1450 parasite eggs per gram faeces). The horse was also infected with mites. After treating the horse with 38g of MAC-P resin, already after 5 days the coprologic examination revealed EPG of < 200 and no more mites were found.

         The faeces of two other horses (horse 2 and 3) were also tested. The table below shows the result of the coprologic tests. The coprologic test was performed after about 10 days after treatment with MAC-P resin.

Table 4 Horses

Treatment of horse 4

Horse 4 was severely infected with parasites. Several treatments with ivermectine, pyrantel, praziquantel and moxidectine, had no result. Apparently, horse 4 was infected with helminths that were resistant to the above anthelmiths (see figure 2A). Additionally, the horse suffered from the side effects caused by the anthelmintics.

Horse 4 was treated with 38 g MAC-P  mixed  with cereal. Already after 10 days, the first signs of healing were seen; the skin and fur of the horse looked healthier. The horse got cured and gained more than 150 kg in weight within two months (see figure 2B).

Treatment of pets

         One cat (see figure 1a) was infected with parasites. After treating the cat with 0, 3 g MAC-P resin, the cat gained weight and lost its parasites (see figure 1b).

         Three dogs were infected with parasites before treatment. These dogs were treated according to their weight (1 g MAC-P resin in a capsule per 15 kg. weight).

The table below shows the result of a coprological test before treatment and one week after treatment.

Table 5 Dogs

Treatment of cows

         Eight cows were infected with parasites before treatment.

Four of these cows (Cow 1,2,3 and 4) were treated according to their weight (1 g MAC-P resin per 15 kg. weight).

Cows 5-8 are a control group: so cows 5,6,7,8 were not treated. These cows have the same amount (or higher) of parasites in the result of the second coprological test.

The table below shows the result of a coprological test before treatment and one week after treatment for cows 1,2,3 and 4.

Cows 5,6,7 and 8 were not treated with MAC-P.

Table 6  Cows

Human treatment
         One person was infected with Toxocara worms, which she most likely obtained from an infected puppy dog that passed the worm to the person. The person got eye damage in one eye due to ocular larva migration.

         The person was treated with 4 g of MAC-P resin, and had after 2 days less appetite. This can be explained by the correlation between appetite and infection with endoparasites that reside in and infect the small and large intestine causing a deficient nutrient intake through the intestine, and an increased appetite and food intake to compensate the nutrient deficiency. MAC-P resin expels the endoparasites and this effect results in a new balance in the body whereby sufficient nutrients are absorbed through the intestine. The person had less desire to eat and the duration of feeling of satiation was much longer than before the intake of MAC-P.
 

Topical treatment of pigeons against ectoparasites

Eight pigeons were infected with ectoparasites. Five of them had lice (Columbicola columbae), three of them had feather mites (Neoknemidocoptes) on or underneath their feathers and their wings. Such type of infection in pigeons is visible.

A liquid preparation of MAC-P resin was made by adding 8g of MAC-P to 80ml water. Three pigeons infected with lice and two pigeons infected with lice were treated by adding one drop of the liquid preparation on the neck of the pigeons, and one drop of the liquid preparation under each wing, using a pipette. The pigeons were not washed after the treatment. Three pigeons were not treated.

After 48 hours, the feathers and wings were checked by a person skilled in the art. The five treated pigeons were no longer infected with lice and mites. The three pigeons that had not been treated were still infected: 2 with lice and 1 with mites in their feathers and underneath their wings.

Two pictures of animals infected with resistant endoparasites :

Figure 1

Cat Mitzi

Fig. 1A before treatment           Fig. 1B after treatment with MAC-P

Horse Barquero XXI (the one Boudewijn de Groot was holding)

 Fig. 2A before treatment                            Fig. 2B after treatment with MAC-P